Click synthesis of ubiquitin dimer analogs to interrogate linkage-specific UBA domain binding.
نویسندگان
چکیده
A new route to the synthesis of triazole-linked ubiquitin dimers (diUbs) as structural analogs of the seven diUbs is reported. Binding studies with the Lys48-specific UBA domain of the Mud1 protein suggest that they represent functionally suitable surrogates of their native counterparts linked by an isopeptide bond.
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عنوان ژورنال:
- Chemical communications
دوره 48 2 شماره
صفحات -
تاریخ انتشار 2012